Dr. Gopal Subramaniam, Dept of Chemistry & Biochemistry


Research Interests:

One of my interests is in the application of NMR spectroscopy and molecular modeling to the structure and dynamics of small and large molecules. Recent work includes mechanism of ring-contraction reactions, fluxional behavior of benzazepines, synthesis and characterization of certain sulfones, and modeling the observed reaction pathways.

In the area of education, particularly educating future science teachers, we have formed a collaboration with in-service teachers to carry out project-based hands-on experimental methods in the classroom and bring the experiential learning to our aspiring teachers and improve teaching methods. Currently I am an active investigator/director in two grants – one is focused on training K-12 science teachers and the other one is focused on course redesign in gateway courses.


Teacher Education Scholarships Available through our grant program:

If you are a sophomore planning for a chem degree Or a post-bac science student, see me for science teacher education program scholarships funded by NSF.  For more info, go to



Recent Publications:

"Clickable, Selective, and Cell-Permeable Activity-Based Probe of Human Cathepsin B – Minimalistic Approach for Enhanced Selectivity" Ashif I. Bhuiyan, Pratikkumar Rathod, Sarbani Ghoshal, Dibyendu Dana, Tuhin Das, Guoshen Li, Anna A. Dickson, Faiza Rafi, Gopal Subramaniam, Karl R. Fath, Suneeta Paroly, Emmanuel J. Chang, Sanjai K. Pathak (2021) Bioorganic Chemistry DOI: https://doi.org/10.1016/j.bioorg.2021.105463

"Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors" Xuwei Shao, Steven Pak, Uday Kiran Velagapudia, Shruthi Gobboorua, Sai Shilpa Kommarajua, Woon-Kai Lowa, Gopal Subramaniam, Sanjai Kumar Pathak, Tanaji T. Talele (2020) Bioorganic Chemistry, 102, 104075, DOI: https://doi.org/10.1016/j.bioorg.2020.104075

“A new synthesis of biologically active pyrroles: Formal synthesis of pentabromopseudilin, bimetopyrol, and several antitubercular agents” Sasan Karimi, Shuai Ma, Michelle Qu, Biling Chen, Keith Ramig, Edyta M. Greer, David J. Szalda, Michelle C. Neary, William F. Berkowitz, Gopal Subramaniam (2019) https://doi.org/10.1002/jhet.3780

“Substituted pyrrole synthesis from nitrodienes” Sasan Karimi, Shuai Ma, Yanan Liu, Keith Ramib, Edyta M. Greer, Kitae Kwon, William F. Berkowitz, Gopal Subramaniam (2017) https://doi.org/10.1016/j.tetlet.2017.04.077

“Interplay of Nitrogen-Atom Inversion and Conformational Inversion in Enantiomerization of 1H-1-Benzazepines” Keith Ramig, Gopal Subramaniam, Sasan Karimi, David J. Szalda, Allen Ko, Aaron Lam, Jeffrey Li, Ani Coaderaj, Leyla Cavdar, Lukasz Bogdan, Kitae Kwon, and Edyta M. Greer (2016) J. Org. Chem., 81 (8), pp 3313–20

"Auto-Tandem Palladium Catalysis: From Isoxazole to 2-Azafluorenone" Das, Sajal; Hong, Dongsub; Chen, Zhiwei; She, Zhigang; Hersh, William; Subramaniam, Gopal; Chen, Yu (2015) Org. Lett.,  17 (22), pp 5578–81

“Oxidative ring-contraction of 3H-1-benzazepines to quinoline derivatives”

Sasan Karimi, Shuai Ma, Keith Ramig, Edyta M. Greer, David J. Szalda, & Gopal Subramaniam (2015) Tet. Lett. 56, 6886-9 doi:10.1016/j.tetlet.2015.10.094

“Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach” Dibyendu Dana, Shatarupa De, Pratikkumar Rathod, Anibal R. Davalos, Daniel A. Novoa, Suneeta Paroly, Viviana M. Torres, Nisar Afzal, Ravi S. Lankalapalli, Susan A. Rotenberg, Emmanuel J. Chang, Gopal Subramaniam and Sanjai Kumar (2014) Chem. Commun. DOI: 10.1039/C4CC04037F

“Regioselective Alkylation Reactions of 2,4-Diphenyl-3H-1-benzazepine give either 3-Alkyl-3H-1-benzazepines or 1-Alkyl-1H-1-benzazepines” Allen Ko, Aaron Lam, Jeffrey Li, Edyta M. Greer, David J. Szalda, Sasan Karimi, Gopal Subramaniam, and Keith Ramig (2014) Tet. Lett. 55, 4386-89.

“Synthesis of Dibenzocyclohepten-5-ones by Electrophilic Iodocyclization of 1-(1,1’-Biphenyl]-2-yl)-alkynones” – Yu Chen, Chenlong Huang, Xiaochen Liu, Eliyahu Perl, Zhiwei Chen, Jieun Namgung, Gopal Subramaniam, Gan Zhang, and William Hersh (2014) J. Org. Chem. 79, 3452-64.

“NMR Spectroscopic and Computational Study of Conformational Isomerism in Substituted 2-Aryl-3H-1-benzazepines: Toward Isolable Atropisomeric Benzazepine Enantiomers” - Keith Ramig, Edyta M. Greer, David J. Szalda, Sasan Karimi, Allen Ko, Laura Boulos, Jiansan Gu, Nathan Dvorkin, Hema Bhramdat, and Gopal Subramaniam (2013) J. Org. Chem 78, 8028-36.

"A Base-Controlled Regioselective Synthesis of Allyl and Vinyl Phenyl Sulfones" - Dibyendu Dana, Anibal R. Davalos, Gopal Subramaniam, Nisar Afzal, William H. Hersh, and Sanjai Kumar (2013) Tet. Lett. 54, 2717-21.

“Development of Cell-Active Non-peptidyl Inhibitors of Cysteine Cathepsins” - Dibyendu Dana, Anibal R. Davalos, Shatarupa De, Pratikkumar Rathod, Ranjith K. Gamage, Juliana Huestis, Nisar Afzal, Yuriy Zavalov, Suneeta S. Paroly, Susan A. Rotenberg, Gopal Subramaniam, Kevin J. Mark, Emmanuel J. Chang, Sanjai Kumar (2013) Bioorg. Med. Chem. 21: 2975-2987.

“Tandem ring-contraction/decarbonylation of 2,4-diphenyl-3H-1-benzazepine to 2,4-diphenylquinoline” - Sasan Karimi, Prakash Prasad, William F. Berkowitz,  Keith Ramig, Edyta Greer, David J. Szalda, and Gopal Subramaniam (2013) Tetrahedron 69: 146-151.


Chemistry in Modern Society (Chem 163), General Chemistry 1 and 2, Practicum in Chemistry Education, Organic Chemistry


Other Activities:

Advisor for ChemEd majors, Science is Fun Club, and Chemical Demonstration Shows. Member of Department Curriculum Committee.

Click here for link to Science is Fun Club


Contact Details:


Dr. Gopal Subramaniam

Remsen 206C

Dept. of Chemistry & Biochemistry

Queens College - CUNY

Queens, NY 11367
Tel: 718-997-4123


High field NMR facility for research and teaching

ChemEd student Joel Heitman demonstrates Exploding Baloon

ChemEd students demonstrating dry ice properties for primary school

Volcano Watermelon Demo by Freida Zavurov



LI-ACS Chem Challenge 2017 Gold Medal (senior category)

LI-ACS Chem Challenge 2017 Bronze Medal (senior category)

LI-ACS Chem Challenge 2015 Gold Medal (senior category)

LI-ACS Chem Challenge 2015 Gold Medal (junior category)