Department of Chemistry and Biochemistry
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Chen Group Publications:

18) Domaradzki, M. E.; Liu, X.; Ong, J.; Yu, G.; Zhang, G.; Simantov, A.; Perl, E.; Chen, Y.* “Triflic Acid Mediated Sequential Cyclization of ortho-Alkynylarylesters with Ammonium Acetate”, Tetrahedron 2020, 76, 131437.


17) Yang, W.; Liu, X.; Leung, P.-H.; Li, Y.; Yang, D.; Chen, Y.* “Iron-Mediated Ring-Opening and Rearrangement Cascade Synthesis of Polysubstituted Pyrroles from 4-Alkenylisoxazoles”, Adv. Synth. Catal. 2020, 362, 1868-1876.


16) Liu, X.; Hong, D.; Sapir, N. G.; Yang, W.; Hersh, W. H.; Leung, P.-H.; Yang, D.; Chen, Y.* “Iron-​Catalyzed Transfer Hydrogenation in Aged N-​Methyl-​2-​pyrrolidone: Reductive Ring-​Opening of 3,​5-​Disubstituted Isoxazoles and Isoxazolines”, J. Org. Chem. 2019, 84, 16204-16213.


15) Yang, W.; Chen, Y.; Yao, Y.; Lin, Q.; Yang, D.* “Iron-​Promoted Reductive Ring-​Opening and Isomerization Reactions of C4-​Alkynylisoxazoles Leading to 2-​Alkynylenaminones and Polysubstituted Furans”, Adv. Synth. Catal. 2019, 361, 5634-5642.


14) Li, X.-R.; Chen, H. J.; Wang, W.; Ma, M.; Chen, Y.; Li, Y.; Pullarkat, S. A.; Leung, P.-H.* “Palladacycle promoted asymmetric hydrophosphination of α,β-unsaturated sulfonylfluorides”, J. Organomet. Chem. 2019, 899, 120912.


13) Yang. W.; Chen, Y.; Yao, Y.; Yang, X.; Lin, Q.; Yang, D.* “ICl/AgNO3 Co-Catalyzed Radical Oxidation of Diaryl- and Alkylarylalkynes into 1,2-Diketones”, J. Org. Chem. 2019, 84, 11080-11090.


12) Li, X. R.; Chen, Y.; Pang, B. P.; Tan, J.; Li, Y.; Pullarkat, S. A.; Leung, P.-H.* “Efficient Synthesis of Malonate Functionalized Chiral Phosphapalladacycles and their Catalytic Evaluation in Asymmetric Hydrophosphination of Chalcone”, Eur. J. Inorg. Chem. 2018, 4385–4390.


11) Liu, X.; Hong, D.; She, Z.; Hersh, W. H.; Yoo, B.; Chen, Y.* “Complementary regioselective synthesis of 3,5-disubstituted isoxazoles from ynones”, Tetrahedron 2018, 74, 6593-6606.


10) Wang, S.; Jia, K.; Cheng, J.; Chen, Y.;* Yuan, Y.* “Dual roles of substituted thiourea as reductant and ligand in CuAAC reaction”, Tetrahedron Lett., 2017, 58, 3717-3721.


9) Ouyang, J.; Su, X.; Chen, Y.; Yuan, Y.;* Li, Y.* “Copper-Catalyzed Carbochlorination or Carbobromination via Radical Cyclization of Aryl Amines”, Tetrahedron Lett., 2016, 57, 1438-1441.

8) Das, S.; Hong, D.; Chen, Z.; She, Z.; Hersh, W. H.; Subramaniam, G.; Chen, Y.* “Auto-Tandem Palladium Catalysis: From Isoxazole to 2-Azafluorenone”, Org. Lett., 2015, 17, 5578-5581.

7) Domaradzki, M. E.; Long, Y.; She, Z.; Liu, X.; Zhang, G.; Chen, Y.* “Gold-Catalyzed Ammonium Acetate-Assisted Cascade Cyclization of 2-Alkynylarylketones”, J. Org. Chem., 2015, 80, 11360-11368.

6) Chen, Y.;* Huang, C.; Liu, X.; Perl, E.; Chen, Z.; Namgung, J.; Subramaniam, G.; Zhang, G.; Hersh, W. H. “Synthesis of Dibenzocyclohepten-5-ones by Electrophilic Iodocyclization of 1-([1,1'-Biphenyl]-2-yl)-alkynones”, J. Org. Chem. 2014, 79, 3452-3464.

5) Chen, Y.;* Liu, X.; Lee, M.; Huang, C.; Inoyatov, I.; Chen, Z.; Perl, A. C.; Hersh, W. H. “ICl-Induced Intramolecular Electrophilic Cyclization of 1-(4'-Methoxy-[1,1'-biphenyl]-2-yl)-alkynones—A Facile Approach to Spiroconjugated Molecules”, Chem. Eur. J. 2013, 19, 9795-9799.

4) Long, Y.; She, Z.; Liu, X.; Chen, Y.* “Synthesis of 1-Aminoisoquinolines by Gold(III)-Mediated Domino Reactions from 2-Alkynylbenzamides and Ammonium Acetate”, J. Org. Chem. 2013, 78, 2579-2588.

3) Yang, D.; Burugupalli, S.; Daniel, D.; Chen, Y.* “Microwave-Assisted One-Pot Synthesis of Isoquinolines, Furopyridines and Thienopyridines by Palladium-Catalyzed Sequential Coupling-Imination-Annulation of 2-Bromoarylaldehydes with Terminal Acetylenes and Ammonium Acetate”, J. Org. Chem. 2012, 77, 4466-4472. [highlighted in SYNFACTS “One-Pot Pd-Catalyzed Synthesis of Isoquinolines and Furo/Thienopyridines.” SYNFACTS 2012, 8, 830.]

2) She, Z.; Niu, D.; Chen, L.; Gunawan, M. A.; Shanja, X.; Hersh, W. H.; Chen, Y.* "Synthesis of Trisubstituted Isoxazoles by Palladium(II)-Catalyzed Cascade Cyclization-Alkenylation of 2-Alkyn-1-one O-Methyl Oximes," J. Org. Chem. 2012, 77, 3627−3633.


1) Long, Y.; Yang, D.;* Zhang, Z.; Wu, Y.; Zeng, H.; Chen, Y.* “Iridium-Catalyzed Asymmetric Ring-Opening of Azabicyclic Alkenes by Amines,” J. Org. Chem. 2010, 75, 7291-7299.